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Intramolecular Heck reaction
The intramolecular Heck reaction (IMHR) is the coupling of an aryl or alkenyl halide with an alkene in the same molecule. The reaction may be used to produce carbocyclic or heterocyclic organic compounds with a variety of ring sizes. Chiral palladium complexes can be used to synthesize chiral intramolecular Heck reaction products in non-racemic form.〔Link, J. T. ''Org. React.'' 2002, ''60'', 157. 〕
==Introduction==
The Heck reaction is the palladium-catalyzed coupling of an aryl or alkenyl halide with an alkene to form a substituted alkene.〔Beletskaya, I.; Cheprakov, A. ''Chem. Rev.'' 2000 ''100'', 3009.〕 Intramolecular variants of the reaction may be used to generate cyclic products containing ''endo'' or ''exo'' double bonds. Ring sizes produced by the intramolecular Heck reaction range from four to twenty-seven atoms. Additionally, in the presence of a chiral palladium catalyst, the intramolecular Heck reaction may be used to establish tertiary or quaternary stereocenters with high enantioselectivity.〔Overman, L. E. ''Pure Appl. Chem.'' 1994, ''66'', 1423.〕 A number of tandem reactions, in which the intermediate alkylpalladium complex is intercepted either intra- or intermolecularly before β-hydride elimination, have also been developed.〔Larock, R. C.; Lee, N. H. ''J. Org. Chem.'' 1991, ''56'', 6253.〕
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抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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